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2015 ; 37
(3
): 190-7
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Resistance of dialyzed patients to erythropoietin
#MMPMID26041422
Alves MT
; Vilaça SS
; Carvalho Md
; Fernandes AP
; Dusse LM
; Gomes KB
Rev Bras Hematol Hemoter
2015[May]; 37
(3
): 190-7
PMID26041422
show ga
Resistance to recombinant human erythropoietin is a common condition in dialyzed
patients with chronic kidney disease and is associated with more
hospitalizations, increased mortality and frequent blood transfusions. The main
cause of hyporesponsiveness to recombinant human erythropoietin in these patients
is iron deficiency. However, a high proportion of patients does not respond to
treatment, even to the use of intravenous iron, which indicates the presence of
other important causes of resistance. In addition to the iron deficiency, the
most common causes of resistance include inflammation, infection, malnutrition,
inadequate dialysis, and hyperparathyroidism, although other factors may be
associated. In the presence of adequate iron stores, other causes should be
investigated and treated appropriately.