Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26728621
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Chromosoma
2016 ; 125
(4
): 607-19
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Resetting a functional G1 nucleus after mitosis
#MMPMID26728621
de Castro IJ
; Gokhan E
; Vagnarelli P
Chromosoma
2016[Sep]; 125
(4
): 607-19
PMID26728621
show ga
The maintenance of the correct cellular information goes beyond the simple
transmission of an intact genetic code from one generation to the next.
Epigenetic changes, topological cues and correct protein-protein interactions
need to be re-established after each cell division to allow the next cell cycle
to resume in the correct regulated manner. This process begins with mitotic exit
and re-sets all the changes that occurred during mitosis thus restoring a
functional G1 nucleus in preparation for the next cell cycle. Mitotic exit is
triggered by inactivation of mitotic kinases and the reversal of their
phosphorylation activities on many cellular components, from nuclear lamina to
transcription factors and chromatin itself. To reverse all these
phosphorylations, phosphatases act during mitotic exit in a timely and spatially
controlled manner directing the events that lead to a functional G1 nucleus. In
this review, we will summarise the recent developments on the control of
phosphatases and their known substrates during mitotic exit, and the key steps
that control the restoration of chromatin status, nuclear envelope reassembly and
nuclear body re-organisation. Although pivotal work has been conducted in this
area in yeast, due to differences between the mitotic exit network between yeast
and vertebrates, we will mainly concentrate on the vertebrate system.
free
free
free
