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10.1016/j.stem.2014.05.008 http://scihub22266oqcxt.onion/10.1016/j.stem.2014.05.008 C4051243!4051243 !24905162     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24905162 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Stem+Cell 2014 ; 14 (6 ): 710-9 Nephropedia Template TP {{tp|p=24905162 |t=2014. Reprogramming the methylome: erasing memory and creating diversity |pdf=|usr=}}{{24905162 }} gab.com Text Reprogramming the methylome: erasing memory and creating diversity JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=24905162 #FOAvip The inheritance of epigenetic marks, in particular DNA methylation, provides a molecular memory that ensures faithful commitment to transcriptional programs during mammalian development. Epigenetic reprogramming results in global hypomethylation of the genome together with a profound loss of memory, which underlies naive pluripotency. Such global reprogramming occurs in primordial germ cells, early embryos, and embryonic stem cells where reciprocal molecular links connect the methylation machinery to pluripotency. Priming for differentiation is initiated upon exit from pluripotency, and we propose that epigenetic mechanisms create diversity of transcriptional states, which help with symmetry breaking during cell fate decisions and lineage commitment. Twit Text FOAVip Reprogramming the methylome: erasing memory and creating diversity ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=24905162 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24905162 #FOAvip English Wikipedia <ref>{{Cite pmid|24905162 }}</ref> Reprogramming the methylome: erasing memory and creating diversity #MMPMID24905162 Lee HJ ; Hore TA ; Reik W Cell Stem Cell 2014[Jun]; 14 (6 ): 710-9 PMID24905162 show ga The inheritance of epigenetic marks, in particular DNA methylation, provides a molecular memory that ensures faithful commitment to transcriptional programs during mammalian development. Epigenetic reprogramming results in global hypomethylation of the genome together with a profound loss of memory, which underlies naive pluripotency. Such global reprogramming occurs in primordial germ cells, early embryos, and embryonic stem cells where reciprocal molecular links connect the methylation machinery to pluripotency. Priming for differentiation is initiated upon exit from pluripotency, and we propose that epigenetic mechanisms create diversity of transcriptional states, which help with symmetry breaking during cell fate decisions and lineage commitment. |Animals [MESH] |DNA Methylation/*genetics [MESH] |Epigenesis, Genetic/*genetics [MESH]Reprogramming the methylome: erasing memory and creating diversity (epmc).pdf DeepDyve Pubget Overpricing