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2017 ; 8
(5
): 328-348
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Reprogramming cell fates by small molecules
#MMPMID28213718
Ma X
; Kong L
; Zhu S
Protein Cell
2017[May]; 8
(5
): 328-348
PMID28213718
show ga
Reprogramming cell fates towards pluripotent stem cells and other cell types has
revolutionized our understanding of cellular plasticity. During the last decade,
transcription factors and microRNAs have become powerful reprogramming factors
for modulating cell fates. Recently, many efforts are focused on reprogramming
cell fates by non-viral and non-integrating chemical approaches. Small molecules
not only are useful in generating desired cell types in vitro for various
applications, such as disease modeling and cell-based transplantation, but also
hold great promise to be further developed as drugs to stimulate patients'
endogenous cells to repair and regenerate in vivo. Here we will focus on chemical
approaches for generating induced pluripotent stem cells, neurons,
cardiomyocytes, hepatocytes and pancreatic ? cells. Significantly, the rapid and
exciting advances in cellular reprogramming by small molecules will help us to
achieve the long-term goal of curing devastating diseases, injuries, cancers and
aging.
free
free
free
