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2015 ; 6
(3
): 858-77
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Replication Stress: A Lifetime of Epigenetic Change
#MMPMID26378584
Khurana S
; Oberdoerffer P
Genes (Basel)
2015[Sep]; 6
(3
): 858-77
PMID26378584
show ga
DNA replication is essential for cell division. Challenges to the progression of
DNA polymerase can result in replication stress, promoting the stalling and
ultimately collapse of replication forks. The latter involves the formation of
DNA double-strand breaks (DSBs) and has been linked to both genome instability
and irreversible cell cycle arrest (senescence). Recent technological advances
have elucidated many of the factors that contribute to the sensing and repair of
stalled or broken replication forks. In addition to bona fide repair factors,
these efforts highlight a range of chromatin-associated changes at and near sites
of replication stress, suggesting defects in epigenome maintenance as a potential
outcome of aberrant DNA replication. Here, we will summarize recent insight into
replication stress-induced chromatin-reorganization and will speculate on
possible adverse effects for gene expression, nuclear integrity and, ultimately,
cell function.
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