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2016 ; 62
(5
): 756-65
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Replicating Large Genomes: Divide and Conquer
#MMPMID27259206
Rivera-Mulia JC
; Gilbert DM
Mol Cell
2016[Jun]; 62
(5
): 756-65
PMID27259206
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Complete duplication of large metazoan chromosomes requires thousands of
potential initiation sites, only a small fraction of which are selected in each
cell cycle. Assembly of the replication machinery is highly conserved and tightly
regulated during the cell cycle, but the sites of initiation are highly flexible,
and their temporal order of firing is regulated at the level of large-scale
multi-replicon domains. Importantly, the number of replication forks must be
quickly adjusted in response to replication stress to prevent genome instability.
Here we argue that large genomes are divided into domains for exactly this
reason. Once established, domain structure abrogates the need for precise
initiation sites and creates a scaffold for the evolution of other chromosome
functions.
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