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2015 ; 309
(9
): R1068-70
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Renal mineralocorticoid receptor and electrolyte homeostasis
#MMPMID26136532
Terker AS
; Ellison DH
Am J Physiol Regul Integr Comp Physiol
2015[Nov]; 309
(9
): R1068-70
PMID26136532
show ga
The renal mineralocorticoid receptor (MR) is a steroid hormone receptor essential
for maintaining electrolyte homeostasis. Its role in mediating effects of
aldosterone was likely vital in enabling the evolution of terrestrial life.
Dysregulated aldosterone-MR signaling has been identified as the cause of
multiple clinical diseases, suggesting the physiological importance of the MR.
While the physiology of this pathway has been studied for over 60 years, only
more recently have genetic mouse models been available to dissect its function in
vivo. This review will focus on recent advances in our knowledge of MR function
with an emphasis on these models.