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2016 ; 1
(4
): e000091
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Renal insufficiency and cancer treatments
#MMPMID27843635
Launay-Vacher V
; Janus N
; Deray G
ESMO Open
2016[]; 1
(4
): e000091
PMID27843635
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Renal insufficiency has been shown to be highly prevalent in patients with
cancer. This renal insufficiency has been reported to be associated with reduced
overall survival and increased cancer-related mortality. Therefore, it is
important to screen patients with cancer for renal insufficiency, using an
adequate and reliable method of estimation of the renal function. Renal
insufficiency may influence 1 or several of the 4 pharmacokinetic phases
(absorption, distribution, metabolism, elimination/excretion), potentially
resulting in marked modifications of the pharmacokinetic profile of a drug in
patients with renal insufficiency. Consequently, it is potentially necessary to
adjust the dosage of anticancer drugs in case of renal insufficiency in order to
avoid drug accumulation and in order to reduce overdosage-related side effects.
This dosage adjustment of anticancer drugs should be performed according to the
level of renal function and with an appropriate and validated method. It is not
always easy to find clear information on anticancer drug handling in these
patients. However, several guidelines, publications and handbooks are available
on how to adjust anticancer drug dosages in patients with renal insufficiency and
will help practitioners to manage anticancer drugs in such patients.
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