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10.4172/jok.1000116 http://scihub22266oqcxt.onion/10.4172/jok.1000116 C4836864!4836864 !27104220     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27104220 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Kidney 2016 ; 2 (1 ): ä Nephropedia Template TP {{tp|p=27104220 |t=2016. Renal Mitochondrial Lipid Peroxidation during Sepsis |pdf=|usr=}}{{27104220 }} gab.com Text Renal Mitochondrial Lipid Peroxidation during Sepsis JO: J Kidney http://www.kidney.de/pget.php?&tw=1&pmid=27104220 #FOAvip Sepsis can provoke kidney injury, which increases mortality. Human and animal studies have documented increased renal oxidative injury and mitochondrial damage during sepsis. However, few studies have attempted to dissect specific renal targets and/or types of oxidative injury using the cecal ligation and puncture (CLP) murine model of sepsis. The purpose of this short communication is to examine the extent of lipid peroxidation within renal mitochondria using CLP and blue native gel electrophoresis which separates intact mitochondrial respiratory complexes. Our results show that CLP induced increased 4-hydroxy-nonenal protein adduction (marker of lipid peroxidation) in renal homogenates and mitochondrial fractions. Blue native gel electrophoresis revealed that respiratory complex III was selectively targeted within mitochondrial fractions. This supports our prior report showing renal complex III inactivation following CLP. Future studies will identify specific renal proteins within complex III that are modified during sepsis to provide mechanistic insight on how mitochondrial respiration is inhibited during sepsis. Twit Text FOAVip Renal Mitochondrial Lipid Peroxidation during Sepsis ????J Kidney http://www.kidney.de/pget.php?&tw=1&pmid=27104220 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27104220 #FOAvip English Wikipedia <ref>{{Cite pmid|27104220 }}</ref> Renal Mitochondrial Lipid Peroxidation during Sepsis #MMPMID27104220 Singh P ; Parajuli N ; Mayeux PR ; MacMillan-Crow LA J Kidney 2016[Feb]; 2 (1 ): ä PMID27104220 show ga Sepsis can provoke kidney injury, which increases mortality. Human and animal studies have documented increased renal oxidative injury and mitochondrial damage during sepsis. However, few studies have attempted to dissect specific renal targets and/or types of oxidative injury using the cecal ligation and puncture (CLP) murine model of sepsis. The purpose of this short communication is to examine the extent of lipid peroxidation within renal mitochondria using CLP and blue native gel electrophoresis which separates intact mitochondrial respiratory complexes. Our results show that CLP induced increased 4-hydroxy-nonenal protein adduction (marker of lipid peroxidation) in renal homogenates and mitochondrial fractions. Blue native gel electrophoresis revealed that respiratory complex III was selectively targeted within mitochondrial fractions. This supports our prior report showing renal complex III inactivation following CLP. Future studies will identify specific renal proteins within complex III that are modified during sepsis to provide mechanistic insight on how mitochondrial respiration is inhibited during sepsis. äRenal Mitochondrial Lipid Peroxidation during Sepsis (epmc).pdf DeepDyve Pubget Overpricing