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Diseases
2018 ; 6
(2
): ? Nephropedia Template TP
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English Wikipedia
Renal Impairment in Chronic Hepatitis B: A Review
#MMPMID29921773
Kamimura H
; Setsu T
; Kimura N
; Yokoo T
; Sakamaki A
; Kamimura K
; Tsuchiya A
; Takamura M
; Yamagiwa S
; Terai S
Diseases
2018[Jun]; 6
(2
): ? PMID29921773
show ga
The liver plays a key role in the metabolism of proteins. Liver dysfunction
affects many organs because it communicates with the spleen and all digestive
organs through the portal vein. Additionally, the kidney is an organ that is
closely related to the liver and is involved in liver diseases.
Glomerulonephritis is an important extrahepatic manifestation of chronic
hepatitis B virus (HBV) infection. Nucleos(t)ide analog (NA) therapy effectively
suppresses HBV replication by inhibiting HBV polymerase, thus decreasing the
levels of serum HBV-DNA and delaying the progression of cirrhosis. Although NA
therapy is recommended for all patients with chronic HBV infection, regardless of
the level of renal dysfunction, there is limited information on NA use in
patients with chronic kidney disease. In addition, in patients with end-stage
liver cirrhosis, hepatorenal syndrome can be fatal. Hence, we should take into
account the stage of impaired renal function in patients with cirrhosis. The aims
of this article are to review the epidemiology, clinical presentation, treatment,
and prevention of HBV-associated nephropathy.