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2015 ; 6
(ä): 257
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Remyelination Therapy in Multiple Sclerosis
#MMPMID26696956
Harlow DE
; Honce JM
; Miravalle AA
Front Neurol
2015[]; 6
(ä): 257
PMID26696956
show ga
Multiple sclerosis (MS) is an immune-mediated disorder of the central nervous
system that results in destruction of the myelin sheath that surrounds axons and
eventual neurodegeneration. Current treatments approved for the treatment of
relapsing forms of MS target the aberrant immune response and successfully reduce
the severity of attacks and frequency of relapses. Therapies are still needed
that can repair damage particularly for the treatment of progressive forms of MS
for which current therapies are relatively ineffective. Remyelination can restore
neuronal function and prevent further neuronal loss and clinical disability.
Recent advancements in our understanding of the molecular and cellular mechanisms
regulating myelination, as well as the development of high-throughput screens to
identify agents that enhance myelination, have lead to the identification of many
potential remyelination therapies currently in preclinical and early clinical
development. One problem that has plagued the development of treatments to
promote remyelination is the difficulty in assessing remyelination in patients
with current imaging techniques. Powerful new imaging technologies are making it
easier to discern remyelination in patients, which is critical for the assessment
of these new therapeutic strategies during clinical trials. This review will
summarize what is currently known about remyelination failure in MS, strategies
to overcome this failure, new therapeutic treatments in the pipeline for
promoting remyelination in MS patients, and new imaging technologies for
measuring remyelination in patients.
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