Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27878945
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cell+Mol+Med
2017 ; 21
(5
): 1013-1023
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Regulatory non-coding RNAs in acute myocardial infarction
#MMPMID27878945
Guo Y
; Luo F
; Liu Q
; Xu D
J Cell Mol Med
2017[May]; 21
(5
): 1013-1023
PMID27878945
show ga
Acute myocardial infarction (AMI) is one of the most common cardiovascular
diseases that leads to high mortality and morbidity globally. Various therapeutic
targets for AMI have been investigated in recent years, including the non-coding
RNAs (ncRNAs). NcRNAs, a class of RNA molecules that typically do not code
proteins, are divided into several subgroups. Among them, microRNAs (miRNAs) are
widely studied for their modulation of several pathological aspects of AMI,
including cardiomyocyte apoptosis, inflammation, angiogenesis and fibrosis. It
has emerged that long ncRNAs (lncRNAs) and circular RNAs (circRNAs) also regulate
these processes via interesting mechanisms. However, the regulatory functions of
ncRNAs in AMI and their underlying functional mechanisms have not been
systematically described. In this review, we summarize the recent findings
involving ncRNA actions in AMI and briefly describe the novel mechanisms of these
ncRNAs, highlighting their potential application as therapeutic targets in AMI.
free
free
free
