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2014 ; 1
(ä): 15
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Regulatory factors of induced pluripotency: current status
#MMPMID27358861
Zhao W
; Ning B
; Qian C
Stem Cell Investig
2014[]; 1
(ä): 15
PMID27358861
show ga
Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs)
through enforced expression of four transcription factors [Oct4, Sox2, Klf4, and
c-Myc (OSKM)]; however, the reprogramming efficiency is extremely low. This
finding raises fundamental questions about the regulators that influence the
change in epigenetic stability and endowment of dedifferentiation potential
during reprogramming. Identification of such regulators is critical to removing
the roadblocks impeding the efficient generation of safe iPSCs and their
successful translation into clinical therapies. In this review, we summarize the
current progress that has been made in understanding cellular reprogramming, with
an emphasis on the molecular mechanisms of epigenetic regulators in induced
pluripotency.