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10.1146/annurev.immunol.25.022106.141623 http://scihub22266oqcxt.onion/10.1146/annurev.immunol.25.022106.141623 C6066374!6066374 !22224781     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22224781 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Immunol 2012 ; 30 (ä): 531-64 Nephropedia Template TP {{tp|p=22224781 |t=2012. Regulatory T cells: mechanisms of differentiation and function |pdf=|usr=}}{{22224781 }} gab.com Text Regulatory T cells: mechanisms of differentiation and function JO: Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=22224781 #FOAvip The immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal microorganisms, immune responses against self and environmental antigens, and metabolic inflammatory disorders. Regulatory T (Treg) cell-mediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation. The discovery that Foxp3 is the transcription factor that specifies the Treg cell lineage facilitated recent progress in understanding the biology of regulatory T cells. In this review, we discuss cellular and molecular mechanisms in the differentiation and function of these cells. Twit Text FOAVip Regulatory T cells: mechanisms of differentiation and function ????Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=22224781 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22224781 #FOAvip English Wikipedia <ref>{{Cite pmid|22224781 }}</ref> Regulatory T cells: mechanisms of differentiation and function #MMPMID22224781 Josefowicz SZ ; Lu LF ; Rudensky AY Annu Rev Immunol 2012[]; 30 (ä): 531-64 PMID22224781 show ga The immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal microorganisms, immune responses against self and environmental antigens, and metabolic inflammatory disorders. Regulatory T (Treg) cell-mediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation. The discovery that Foxp3 is the transcription factor that specifies the Treg cell lineage facilitated recent progress in understanding the biology of regulatory T cells. In this review, we discuss cellular and molecular mechanisms in the differentiation and function of these cells. |Animals [MESH] |Cell Differentiation [MESH] |Cytokines/immunology/metabolism [MESH] |Enzyme Activation [MESH] |Forkhead Transcription Factors/genetics/metabolism [MESH] |Gene Expression Regulation [MESH] |Homeostasis/immunology [MESH] |Humans [MESH] |Immune Tolerance [MESH] |MicroRNAs/immunology/metabolism [MESH] |Protein Binding [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Receptors, Antigen, T-Cell/immunology/metabolism [MESH] |Signal Transduction [MESH] |T-Lymphocytes, Regulatory/cytology/*immunology/metabolism [MESH] |Thymus Gland/immunology/metabolism [MESH]Regulatory T cells: mechanisms of differentiation and function (epmc).pdf DeepDyve Pubget Overpricing