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10.1038/cmi.2015.12

http://scihub22266oqcxt.onion/10.1038/cmi.2015.12
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C4579652!4579652!25942597
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suck abstract from ncbi


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pmid25942597      Cell+Mol+Immunol 2015 ; 12 (5): 525-32
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  • Regulatory T cells turn pathogenic #MMPMID25942597
  • Guo J; Zhou X
  • Cell Mol Immunol 2015[Sep]; 12 (5): 525-32 PMID25942597show ga
  • Foxp3+ regulatory T (Treg) cells are considered a sub-lineage of CD4+ T cells that are protective against autoimmunity due to their essential roles in maintaining immune homeostasis and self-tolerance. However, Treg cells are unstable in vivo in terms of lineage specialization and suppressive function. These unstable Treg cells play roles in the pathogenesis of diseases, which cause safety concerns regarding human Treg cell therapy. In this review, we highlight recent findings that demonstrate the pathogenic conversion of Treg cells in different disease models.
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