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10.1016/j.jaci.2016.06.003 http://scihub22266oqcxt.onion/10.1016/j.jaci.2016.06.003 C5023156!5023156 !27596705     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27596705 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Allergy+Clin+Immunol 2016 ; 138 (3 ): 639-652 Nephropedia Template TP {{tp|p=27596705 |t=2016. Regulatory T cells in allergic diseases |pdf=|usr=}}{{27596705 }} gab.com Text Regulatory T cells in allergic diseases JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27596705 #FOAvip The pathogenesis of allergic diseases entails an ineffective tolerogenic immune response to allergens. Regulatory T (Treg) cells play a key role in sustaining immune tolerance to allergens, yet mechanisms by which Treg cells fail to maintain tolerance in patients with allergic diseases are not well understood. We review current concepts and established mechanisms regarding how Treg cells regulate different components of allergen-triggered immune responses to promote and maintain tolerance. We will also discuss more recent advances that emphasize the "dual" functionality of Treg cells in patients with allergic diseases: how Treg cells are essential in promoting tolerance to allergens but also how a proallergic inflammatory environment can skew Treg cells toward a pathogenic phenotype that aggravates and perpetuates disease. These advances highlight opportunities for novel therapeutic strategies that aim to re-establish tolerance in patients with chronic allergic diseases by promoting Treg cell stability and function. Twit Text FOAVip Regulatory T cells in allergic diseases ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27596705 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27596705 #FOAvip English Wikipedia <ref>{{Cite pmid|27596705 }}</ref> Regulatory T cells in allergic diseases #MMPMID27596705 Noval Rivas M ; Chatila TA J Allergy Clin Immunol 2016[Sep]; 138 (3 ): 639-652 PMID27596705 show ga The pathogenesis of allergic diseases entails an ineffective tolerogenic immune response to allergens. Regulatory T (Treg) cells play a key role in sustaining immune tolerance to allergens, yet mechanisms by which Treg cells fail to maintain tolerance in patients with allergic diseases are not well understood. We review current concepts and established mechanisms regarding how Treg cells regulate different components of allergen-triggered immune responses to promote and maintain tolerance. We will also discuss more recent advances that emphasize the "dual" functionality of Treg cells in patients with allergic diseases: how Treg cells are essential in promoting tolerance to allergens but also how a proallergic inflammatory environment can skew Treg cells toward a pathogenic phenotype that aggravates and perpetuates disease. These advances highlight opportunities for novel therapeutic strategies that aim to re-establish tolerance in patients with chronic allergic diseases by promoting Treg cell stability and function. |Adaptive Immunity [MESH] |Animals [MESH] |Forkhead Transcription Factors/immunology [MESH] |Humans [MESH] |Hypersensitivity/*immunology [MESH] |Immunity, Innate [MESH] |Regeneration [MESH]Regulatory T cells in allergic diseases (epmc).pdf DeepDyve Pubget Overpricing