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10.1038/nri.2015.1

http://scihub22266oqcxt.onion/10.1038/nri.2015.1
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C5113825!5113825!26688349
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suck abstract from ncbi


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pmid26688349      Nat+Rev+Immunol 2016 ; 16 (2): 90-101
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  • Regulatory T cell memory #MMPMID26688349
  • Rosenblum MD; Way SS; Abbas AK
  • Nat Rev Immunol 2016[Feb]; 16 (2): 90-101 PMID26688349show ga
  • Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte populations show an increase in number and function after antigen encounter and more rapidly re-expand upon subsequent antigen exposure. Studies of immune memory have primarily focused on effector B cells and T cells with microbial specificity, using prime challenge models of infection. However, recent work has also identified persistently expanded populations of antigen-specific regulatory T cells that protect against aberrant immune responses. In this Review, we consider the parallels between memory effector T cells and memory regulatory T cells, along with the functional implications of regulatory memory in autoimmunity, antimicrobial host defence and maternal fetal tolerance. In addition, we discuss emerging evidence for regulatory T cell memory in humans and key unanswered questions in this rapidly evolving field.
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