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10.1016/j.it.2015.04.006

http://scihub22266oqcxt.onion/10.1016/j.it.2015.04.006
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pmid25981968      Trends+Immunol 2015 ; 36 (6): 344-53
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  • Regulatory T cell identity: formation and maintenance #MMPMID25981968
  • Li X; Zheng Y
  • Trends Immunol 2015[Jun]; 36 (6): 344-53 PMID25981968show ga
  • T regulatory (Treg) cells are central to the maintenance of immune homeostasis. The transcription factor Foxp3 is essential for specifying the Treg cell lineage during development, and continued expression of Foxp3 in mature Treg cells is necessary for suppressive function. Treg cells can lose Foxp3 expression under certain conditions, and this is associated with autoimmune pathology. Here we review recent insights into the mechanisms that maintain Treg cell stability and function, and place these findings within the broader understanding of mechanisms that establish Treg cell identity during development. We integrate emerging principles in Treg cell lineage maintenance with the mechanisms that allow Treg cells to sense and respond to varied inflammatory environments, and outline important areas of future inquiry in this context.
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