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Cancer+Immunol+Res
2016 ; 4
(9
): 721-5
Nephropedia Template TP gab.com Text Twit Text FOAVip Twit Text # English Wikipedia
Regulatory T Cells: Differentiation and Function
#MMPMID27590281
Plitas G
; Rudensky AY
Cancer Immunol Res
2016[Sep]; 4
(9
): 721-5
PMID27590281
show ga
The immune system of vertebrate animals has evolved to mount an effective defense
against a diverse set of pathogens while minimizing transient or lasting
impairment in tissue function that could result from the inflammation caused by
immune responses to infectious agents. In addition, misguided immune responses to
"self" and dietary antigens, as well as to commensal microorganisms, can lead to
a variety of inflammatory disorders, including autoimmunity, metabolic syndrome,
allergies, and cancer. Regulatory T cells expressing the X chromosome-linked
transcription factor Foxp3 suppress inflammatory responses in diverse biological
settings and serve as a vital mechanism of negative regulation of immune-mediated
inflammation. Cancer Immunol Res; 4(9); 721-5. ©2016 AACR.
Please enable JavaScript to view the comments powered by Disqus. |*Cell Differentiation
[MESH] |Animals
[MESH] |Autoimmunity
[MESH] |Cell Lineage/genetics
[MESH] |Disease Susceptibility
[MESH] |Forkhead Transcription Factors/genetics/metabolism
[MESH] |Gene Expression Regulation
[MESH] |Humans
[MESH] |Immunity
[MESH] |Immunomodulation
[MESH] |Signal Transduction
[MESH] |T-Lymphocyte Subsets/immunology/metabolism
[MESH] |T-Lymphocytes, Regulatory/*cytology/*physiology
[MESH] DeepDyve Pubget Overpricing