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10.1074/jbc.M115.708560 http://scihub22266oqcxt.onion/10.1074/jbc.M115.708560 C4933219!4933219 !27056325     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27056325 &cmd=llinks): Failed to open stream: HTTP request failed! 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Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition |pdf=|usr=}}{{27056325 }} gab.com Text Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27056325 #FOAvip Covalent modification of histones is a fundamental mechanism of regulated gene expression in eukaryotes, and interpretation of histone modifications is an essential feature of epigenetic control. Bromodomains are specialized binding modules that interact with acetylated histones, linking chromatin recognition to gene transcription. Because of their ability to function in a domain-specific fashion, selective disruption of bromodomain:acetylated histone interactions with chemical probes serves as a powerful means for understanding biological processes regulated by these chromatin adaptors. Here we describe the discovery and characterization of potent and selective small molecule inhibitors for the bromodomains of CREBBP/EP300 that engage their target in cellular assays. We use these tools to demonstrate a critical role for CREBBP/EP300 bromodomains in regulatory T cell biology. Because regulatory T cell recruitment to tumors is a major mechanism of immune evasion by cancer cells, our data highlight the importance of CREBBP/EP300 bromodomain inhibition as a novel, small molecule-based approach for cancer immunotherapy. Twit Text FOAVip Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27056325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27056325 #FOAvip English Wikipedia <ref>{{Cite pmid|27056325 }}</ref> Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition #MMPMID27056325 Ghosh S ; Taylor A ; Chin M ; Huang HR ; Conery AR ; Mertz JA ; Salmeron A ; Dakle PJ ; Mele D ; Cote A ; Jayaram H ; Setser JW ; Poy F ; Hatzivassiliou G ; DeAlmeida-Nagata D ; Sandy P ; Hatton C ; Romero FA ; Chiang E ; Reimer T ; Crawford T ; Pardo E ; Watson VG ; Tsui V ; Cochran AG ; Zawadzke L ; Harmange JC ; Audia JE ; Bryant BM ; Cummings RT ; Magnuson SR ; Grogan JL ; Bellon SF ; Albrecht BK ; Sims RJ 3rd ; Lora JM J Biol Chem 2016[Jun]; 291 (25 ): 13014-27 PMID27056325 show ga Covalent modification of histones is a fundamental mechanism of regulated gene expression in eukaryotes, and interpretation of histone modifications is an essential feature of epigenetic control. Bromodomains are specialized binding modules that interact with acetylated histones, linking chromatin recognition to gene transcription. Because of their ability to function in a domain-specific fashion, selective disruption of bromodomain:acetylated histone interactions with chemical probes serves as a powerful means for understanding biological processes regulated by these chromatin adaptors. Here we describe the discovery and characterization of potent and selective small molecule inhibitors for the bromodomains of CREBBP/EP300 that engage their target in cellular assays. We use these tools to demonstrate a critical role for CREBBP/EP300 bromodomains in regulatory T cell biology. Because regulatory T cell recruitment to tumors is a major mechanism of immune evasion by cancer cells, our data highlight the importance of CREBBP/EP300 bromodomain inhibition as a novel, small molecule-based approach for cancer immunotherapy. |Acetylation/drug effects [MESH] |CREB-Binding Protein/*antagonists & inhibitors/chemistry/metabolism [MESH] |Cell Differentiation/drug effects [MESH] |Cell Line [MESH] |Cells, Cultured [MESH] |E1A-Associated p300 Protein/*antagonists & inhibitors/chemistry/metabolism [MESH] |Forkhead Transcription Factors/metabolism [MESH] |Histones/metabolism [MESH] |Humans [MESH] |Molecular Docking Simulation [MESH] |Protein Structure, Tertiary/drug effects [MESH] |Small Molecule Libraries/*chemistry/*pharmacology [MESH] |T-Lymphocytes, Regulatory/cytology/*drug effects/metabolism [MESH]Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition (epmc).pdf DeepDyve Pubget Overpricing