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2011 ; 8
(2
): 96-111
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Regulatory Interactions in the Bone Marrow Microenvironment
#MMPMID26213605
Smith JN
; Calvi LM
IBMS Bonekey
2011[]; 8
(2
): 96-111
PMID26213605
show ga
Hematopoietic stem cells (HSCs) are the immature, pluripotent cells from which
all myeloid and lymphoid cell types originate. As stem cells, HSCs are capable of
two very different fate choices: self-renewal, ensuring they will persist
throughout the lifetime of an organism, and differentiation to mature progeny.
Therapeutic applications of HSCs include their routine use in stem cell
transplantation to treat hematopoietic malignancies or bone marrow failure.
Research and clinical experience have provided tools for the immunophenotypic
identification and functional analysis of HSCs and there is increasing evidence
suggesting that HSC regulation is greatly influenced by signals from their niches
in the bone marrow. Although they represent one of the most rigorously studied
stem cell types, still more remains to be known about how HSCs are regulated and
respond to stress conditions.