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2017 ; 16
(1
): 3-10
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Regulatory B cells in infectious disease (Review)
#MMPMID28534949
Dai YC
; Zhong J
; Xu JF
Mol Med Rep
2017[Jul]; 16
(1
): 3-10
PMID28534949
show ga
Regulatory B cells (Bregs) are a subset of B cells, which reportedly exert
significant immunomodulatory effects through the production of interleukin
(IL)?10, IL?35 and transforming growth factor??. Over the last decade, studies
have indicated that Bregs function in autoimmune and allergic diseases through
antigen?specific and non?specific immunoregulatory mechanisms. However, only a
limited number of reviews have focused on the role of Bregs during infection,
particularly their functions in intracellular infections. The present review
discusses the role of Bregs in infectious diseases in animal models and human
studies, and provides an overview of the immunoregulatory mechanisms used by
Bregs.