Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26124722
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Physiol
2015 ; 6
(ä): 166
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Regulators of Slc4 bicarbonate transporter activity
#MMPMID26124722
Thornell IM
; Bevensee MO
Front Physiol
2015[]; 6
(ä): 166
PMID26124722
show ga
The Slc4 family of transporters is comprised of anion exchangers (AE1-4),
Na(+)-coupled bicarbonate transporters (NCBTs) including electrogenic
Na/bicarbonate cotransporters (NBCe1 and NBCe2), electroneutral Na/bicarbonate
cotransporters (NBCn1 and NBCn2), and the electroneutral Na-driven Cl-bicarbonate
exchanger (NDCBE), as well as a borate transporter (BTR1). These transporters
regulate intracellular pH (pHi) and contribute to steady-state pHi, but are also
involved in other physiological processes including CO2 carriage by red blood
cells and solute secretion/reabsorption across epithelia. Acid-base transporters
function as either acid extruders or acid loaders, with the Slc4 proteins moving
HCO(-) 3 either into or out of cells. According to results from both molecular
and functional studies, multiple Slc4 proteins and/or associated splice variants
with similar expected effects on pHi are often found in the same tissue or cell.
Such apparent redundancy is likely to be physiologically important. In addition
to regulating pHi, a HCO(-) 3 transporter contributes to a cell's ability to fine
tune the intracellular regulation of the cotransported/exchanged ion(s) (e.g.,
Na(+) or Cl(-)). In addition, functionally similar transporters or splice
variants with different regulatory profiles will optimize pH physiology and
solute transport under various conditions or within subcellular domains. Such
optimization will depend on activated signaling pathways and transporter
expression profiles. In this review, we will summarize and discuss both
well-known and more recently identified regulators of the Slc4 proteins. Some of
these regulators include traditional second messengers, lipids, binding proteins,
autoregulatory domains, and less conventional regulators. The material presented
will provide insight into the diversity and physiological significance of
multiple members within the Slc4 gene family.
free
free
free
