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2014 ; 1
(1
): e29910
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Regulation of viral oncogenesis by microRNAs
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; Ye Q
Mol Cell Oncol
2014[]; 1
(1
): e29910
PMID27308317
show ga
Viral infection may play a causative role in human cancers, for example hepatitis
B virus (HBV) or hepatitis C virus (HCV) in liver cancer, human papilloma virus
(HPV) in cervical cancer, and Epstein-Barr virus (EBV) in nasopharyngeal
carcinoma. Virally infected cells express viral-encoded genes that are critical
for oncogenesis. Some viruses also encode microRNA (miRNA) species. miRNAs are
small noncoding RNA molecules that play an important role in cancer development
and progression. Recent studies indicate an important interplay among viral
oncoproteins, virus-encoded miRNAs, cellular miRNAs, and cellular genes. This
review focuses on modulation of HBV-, HCV-, HPV-, and EBV-associated cancers by
cellular and/or viral miRNA. An understanding of the mechanisms underlying the
regulation of viral carcinogenesis by miRNAs may provide new targets for the
development of specific viral therapies.