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2017 ; 8
(4
): 220-231
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Regulation of transcription factors by sumoylation
#MMPMID28379052
Rosonina E
; Akhter A
; Dou Y
; Babu J
; Sri Theivakadadcham VS
Transcription
2017[Aug]; 8
(4
): 220-231
PMID28379052
show ga
Transcription factors (TFs) are among the most frequently detected targets of
sumoylation, and effects of the modification have been studied for about 200
individual TFs to date. TF sumoylation is most often associated with reduced
target gene expression, which can be mediated by enhanced interactions with
corepressors or by interference with protein modifications that promote
transcription. However, recent studies show that sumoylation also regulates gene
expression by controlling the levels of TFs that are associated with chromatin.
SUMO can mediate this by modulating TF DNA-binding activity, promoting clearance
of TFs from chromatin, or indirectly, by influencing TF abundance or
localization.