Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27236363
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27236363
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Trends+Immunol
2016 ; 37
(7
): 427-439
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Regulation of the T Cell Response by CD39
#MMPMID27236363
Takenaka MC
; Robson S
; Quintana FJ
Trends Immunol
2016[Jul]; 37
(7
): 427-439
PMID27236363
show ga
The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes
the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under
conditions of inflammatory stress and cell injury. CD39 generates AMP, which is
in turn used by the ecto-5'-nucleotidase CD73 to synthesize adenosine. These
ectonucleotidases have a major impact on the dynamic equilibrium of
proinflammatory eATP and ADP nucleotides versus immunosuppressive adenosine
nucleosides. Indeed, CD39 plays a dominant role in the purinergic regulation of
inflammation and the immune response because its expression is influenced by
genetic and environmental factors. We review the specific role of CD39 in the
kinetic regulation of cellular immune responses in the evolution of disease. We
focus on the effects of CD39 on T cells and explore potential clinical
applications in autoimmunity, chronic infections, and cancer.
free
free
free
