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Regulation of stem cell function by protein ubiquitylation
#MMPMID24652853
Strikoudis A
; Guillamot M
; Aifantis I
EMBO Rep
2014[Apr]; 15
(4
): 365-82
PMID24652853
show ga
Tissue homeostasis depends largely on the ability to replenish impaired or aged
cells. Thus, tissue-resident stem cells need to provide functional progeny
throughout the lifetime of an organism. Significant work in the past years has
characterized how stem cells integrate signals from their environment to shape
regulatory transcriptional networks and chromatin-regulating factors that control
stem cell differentiation or maintenance. There is increasing interest in how
post-translational modifications, and specifically ubiquitylation, control these
crucial decisions. Ubiquitylation modulates the stability and function of
important factors that regulate key processes in stem cell behavior. In this
review, we analyze the role of ubiquitylation in embryonic stem cells and
different adult multipotent stem cell systems and discuss the underlying
mechanisms that control the balance between quiescence, self-renewal, and
differentiation. We also discuss deregulated processes of ubiquitin-mediated
protein degradation that lead to the development of tumor-initiating cells.
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