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10.1080/01902140801925471 http://scihub22266oqcxt.onion/10.1080/01902140801925471 C5524512!5524512 !18432456     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18432456 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Lung+Res 2008 ; 34 (4 ): 195-208 Nephropedia Template TP {{tp|p=18432456 |t=2008. Regulation of pulmonary vasoconstriction by agonists and caveolae |pdf=|usr=}}{{18432456 }} gab.com Text Regulation of pulmonary vasoconstriction by agonists and caveolae JO: Exp Lung Res http://www.kidney.de/pget.php?&tw=1&pmid=18432456 #FOAvip Sustained pulmonary vasoconstriction contributes to the elevated pulmonary vascular resistance observed in pulmonary arterial hypertension. A rise in cytosolic Ca(2 +) in pulmonary artery smooth muscle cells (PASMCs) is major trigger for pulmonary vasoconstriction. One family of drugs currently being pursued as a potential treatment for pulmonary hypertension are the statins, which act by depleting cholesterol and reducing the number of caveolae. This study aimed at investigating the role of caveolae, membrane receptors, and ion channels (that are potentially located in the caveolae) in agonist-mediated pulmonary vasoconstriction in order to gain a greater understanding of the signaling mechanisms involved in the regulation of pulmonary vascular tone. Chronic treatment of PASMCs with the cholesterol-depleting agent, methyl-beta -cyclodextrin (Mbeta CD), significantly reduced the number of cholesterol rich caveolae regions in the membrane. This disruption of cholesterol in caveolae significantly inhibited pharmacomechanical (induced by phenylephrine), but not electromechanical (induced by elevated extracellular potassium concentration), rat pulmonary artery contraction. These results indicate that receptors may functionally colocalize in caveolae in PASMCs and coordinate to regulate pulmonary vascular tone. Twit Text FOAVip Regulation of pulmonary vasoconstriction by agonists and caveolae ????Exp Lung Res http://www.kidney.de/pget.php?&tw=1&pmid=18432456 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18432456 #FOAvip English Wikipedia <ref>{{Cite pmid|18432456 }}</ref> Regulation of pulmonary vasoconstriction by agonists and caveolae #MMPMID18432456 Schach C ; Firth AL ; Xu M ; Remillard CV ; Patel HH ; Insel PA ; Yuan JX Exp Lung Res 2008[May]; 34 (4 ): 195-208 PMID18432456 show ga Sustained pulmonary vasoconstriction contributes to the elevated pulmonary vascular resistance observed in pulmonary arterial hypertension. A rise in cytosolic Ca(2 +) in pulmonary artery smooth muscle cells (PASMCs) is major trigger for pulmonary vasoconstriction. One family of drugs currently being pursued as a potential treatment for pulmonary hypertension are the statins, which act by depleting cholesterol and reducing the number of caveolae. This study aimed at investigating the role of caveolae, membrane receptors, and ion channels (that are potentially located in the caveolae) in agonist-mediated pulmonary vasoconstriction in order to gain a greater understanding of the signaling mechanisms involved in the regulation of pulmonary vascular tone. Chronic treatment of PASMCs with the cholesterol-depleting agent, methyl-beta -cyclodextrin (Mbeta CD), significantly reduced the number of cholesterol rich caveolae regions in the membrane. This disruption of cholesterol in caveolae significantly inhibited pharmacomechanical (induced by phenylephrine), but not electromechanical (induced by elevated extracellular potassium concentration), rat pulmonary artery contraction. These results indicate that receptors may functionally colocalize in caveolae in PASMCs and coordinate to regulate pulmonary vascular tone. |Adrenergic alpha-Agonists/*pharmacology [MESH] |Animals [MESH] |Calcium/metabolism [MESH] |Caveolae/drug effects/*physiology [MESH] |Cell Membrane/drug effects/physiology [MESH] |Cholesterol/metabolism [MESH] |Endothelium, Vascular/drug effects/physiology [MESH] |In Vitro Techniques [MESH] |Male [MESH] |Phenylephrine/pharmacology [MESH] |Pulmonary Artery/*drug effects/*physiology [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Vasoconstriction/drug effects/physiology [MESH] |Vasoconstrictor Agents/*pharmacology [MESH]Regulation of pulmonary vasoconstriction by agonists and caveolae (epmc).pdf DeepDyve Pubget Overpricing