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2014 ; 21
(1
): 15-25
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Regulation of placental angiogenesis
#MMPMID23981199
Chen DB
; Zheng J
Microcirculation
2014[Jan]; 21
(1
): 15-25
PMID23981199
show ga
Ample interest has been evoked in using placental angiogenesis as a target for
the development of diagnosis tools and potential therapeutics for pregnancy
complications based on the knowledge of placental angiogenesis in normal and
aberrant pregnancies. Although these goals are still far from reach, one would
expect that two complementary processes should be balanced for therapeutic
angiogenesis to be successful in restoring a mature and functional vascular
network in the placenta in any pregnancy complication: (i) pro-angiogenic
stimulation of new vessel growth and (ii) anti-angiogenic inhibition of vessel
overgrowth. As the best model of physiological angiogenesis, investigations of
placental angiogenesis provide critical insights not only for better
understanding of normal placental endothelial biology but also for the
development of diagnosis tools for pregnancy complications. Such investigations
will potentially identify novel pro-angiogenic factors for therapeutic
intervention for tissue damage in various obstetric complications or heart
failure or anti-angiogenic factors to target on cancer or vision loss in which
circulation needs to be constrained. This review summarizes the genetic and
molecular aspects of normal placental angiogenesis as well as the signaling
mechanisms by which the dominant angiogenic factor vascular endothelial growth
factor regulates placental angiogenesis with a focus on placental endothelial
cells.
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