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2014 ; 40
(4
): 419-24
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Regulation of mitochondrial morphology by lipids
#MMPMID24771456
Ha EE
; Frohman MA
Biofactors
2014[Jul]; 40
(4
): 419-24
PMID24771456
show ga
Although great progress has been made in identifying key protein factors that
regulate mitochondrial morphology through mediating fission and fusion, signaling
lipids are increasingly being recognized as important in the process as well. We
review here roles that have been proposed for the signaling and bulk lipids
cardiolipin, phosphatidic acid, lysophosphatidic acid, diacylglycerol, and
phosphatidylethanolamine and the enzymes that generate or catabolize them in the
regulation of mitochondrial morphology in yeast and mammals. Mutations in some of
these enzymes are causal in a number of disease settings, highlighting the
significance of controlling the lipid environment in this setting.