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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Arterioscler+Thromb+Vasc+Biol
2012 ; 32
(9
): 2097-103
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Regulation of lymphocyte function by adenosine
#MMPMID22772752
Linden J
; Cekic C
Arterioscler Thromb Vasc Biol
2012[Sep]; 32
(9
): 2097-103
PMID22772752
show ga
Adenosine regulates the interaction between lymphocytes and the vasculature, and
is important for controlling lymphocyte trafficking in response to tissue injury
or infection. Adenosine can blunt the effects of T cell receptor activation
primarily by activating adenosine A(2A) receptors and signaling via cyclic AMP
and protein kinase A. Protein kinase A reduces proximal T cell receptor signaling
by phosphorylation of C-terminal Src kinase, nuclear factor of activated T cells
and cyclic AMP response element-binding protein. Protein kinase A activation can
either enhance or inhibit the survival of T cells depending on the strength and
duration of signaling. Inducible enzymes such as CD73 and CD39 regulate adenosine
formation and degradation in vivo. The extravasation of lymphocytes through blood
vessels is influenced by A(2A) receptors-mediated suppression of intercellular
adhesion molecule 1 expression on lymphocytes and diminished production of
interferon ? and interferon ?-inducible chemokines that are chemotactic to
activated lymphocytes. Adenosine also decreases the barrier function of vascular
endothelium by activating A(2B)Rs. In sum, adenosine signaling is influenced by
tissue inflammation and injury through induction of receptors and enzymes and has
generally inhibitory effects on lymphocyte migration into inflamed tissues due to
protein kinase A-mediated effects on adhesion molecules, interferon ? production,
and endothelial barrier function.
|*Signal Transduction
[MESH]
|Adenosine/*metabolism
[MESH]
|Animals
[MESH]
|Antigen-Presenting Cells/metabolism
[MESH]
|Cell Adhesion Molecules/metabolism
[MESH]
|Cyclic AMP-Dependent Protein Kinases/metabolism
[MESH]
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