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2014 ; 143
(2
): 131-7
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Regulation of immune responses by proton channels
#MMPMID24890927
Capasso M
Immunology
2014[Oct]; 143
(2
): 131-7
PMID24890927
show ga
The identification of the HVCN1 gene, encoding the only mammalian voltage-gated
proton channel, prompted a number of studies on how proton channels affect
cellular functions. As their expression is mainly restricted to immune cells, it
is not surprising that proton channels regulate different aspects of immune
responses. In this review, I will examine the current knowledge of voltage-gated
proton channels in both innate and adaptive responses and assess the remaining
outstanding questions.