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10.1111/imm.12326

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C4172129!4172129 !24890927
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suck abstract from ncbi


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pmid24890927
      Immunology 2014 ; 143 (2 ): 131-7
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  • Regulation of immune responses by proton channels #MMPMID24890927
  • Capasso M
  • Immunology 2014[Oct]; 143 (2 ): 131-7 PMID24890927 show ga
  • The identification of the HVCN1 gene, encoding the only mammalian voltage-gated proton channel, prompted a number of studies on how proton channels affect cellular functions. As their expression is mainly restricted to immune cells, it is not surprising that proton channels regulate different aspects of immune responses. In this review, I will examine the current knowledge of voltage-gated proton channels in both innate and adaptive responses and assess the remaining outstanding questions.
  • |*Adaptive Immunity [MESH]
  • |*Immunity, Innate [MESH]
  • |Animals [MESH]
  • |Dendritic Cells/immunology/metabolism [MESH]
  • |Humans [MESH]
  • |Ion Channel Gating [MESH]
  • |Ion Channels/immunology/*metabolism [MESH]
  • |Leukocytes/immunology/*metabolism [MESH]
  • |Macrophages/immunology/metabolism [MESH]
  • |Protons [MESH]


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