Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27250345
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Hematol
2016 ; 104
(3
): 310-23
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Regulation of hematopoietic development by ZBTB transcription factors
#MMPMID27250345
Maeda T
Int J Hematol
2016[Sep]; 104
(3
): 310-23
PMID27250345
show ga
Hematopoietic development is governed by the coordinated expression of lineage-
and differentiation stage-specific genes. Transcription factors play major roles
in this process and their perturbation may underlie hematologic and immunologic
disorders. Nearly 1900 transcription factors are encoded in the human genome: of
these, 49 BTB (for broad-complex, tram-track and bric à brac)-zinc finger
transcription factors referred to as ZBTB or POK proteins have been identified.
ZBTB proteins, including BCL6, PLZF, ThPOK and LRF, exhibit a broad spectrum of
functions in normal and malignant hematopoiesis. This review summarizes
developmental and molecular functions of ZBTB proteins relevant to hematology.