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10.15252/emmm.201404571 http://scihub22266oqcxt.onion/10.15252/emmm.201404571 C4459814!4459814 !25851537     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25851537 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+Mol+Med 2015 ; 7 (6 ): 714-34 Nephropedia Template TP {{tp|p=25851537 |t=2015. Regulation of hematogenous tumor metastasis by acid sphingomyelinase |pdf=|usr=}}{{25851537 }} gab.com Text Regulation of hematogenous tumor metastasis by acid sphingomyelinase JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25851537 #FOAvip Metastatic dissemination of cancer cells is the ultimate hallmark of malignancy and accounts for approximately 90% of human cancer deaths. We investigated the role of acid sphingomyelinase (Asm) in the hematogenous metastasis of melanoma cells. Intravenous injection of B16F10 melanoma cells into wild-type mice resulted in multiple lung metastases, while Asm-deficient mice (Smpd1(-/-) mice) were protected from pulmonary tumor spread. Transplanting wild-type platelets into Asm-deficient mice reinstated tumor metastasis. Likewise, Asm-deficient mice were protected from hematogenous MT/ret melanoma metastasis to the spleen in a mouse model of spontaneous tumor metastasis. Human and mouse melanoma cells triggered activation and release of platelet secretory Asm, in turn leading to ceramide formation, clustering, and activation of ?5?1 integrins on melanoma cells finally leading to adhesion of the tumor cells. Clustering of integrins by applying purified Asm or C16 ceramide to B16F10 melanoma cells before intravenous injection restored trapping of tumor cells in the lung in Asm-deficient mice. This effect was revertable by arginine-glycine-aspartic acid peptides, which are known inhibitors of integrins, and by antibodies neutralizing ?1 integrins. These findings indicate that melanoma cells employ platelet-derived Asm for adhesion and metastasis. Twit Text FOAVip Regulation of hematogenous tumor metastasis by acid sphingomyelinase ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25851537 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25851537 #FOAvip English Wikipedia <ref>{{Cite pmid|25851537 }}</ref> Regulation of hematogenous tumor metastasis by acid sphingomyelinase #MMPMID25851537 Carpinteiro A ; Becker KA ; Japtok L ; Hessler G ; Keitsch S ; Po?gajovŕ M ; Schmid KW ; Adams C ; Müller S ; Kleuser B ; Edwards MJ ; Grassmé H ; Helfrich I ; Gulbins E EMBO Mol Med 2015[Jun]; 7 (6 ): 714-34 PMID25851537 show ga Metastatic dissemination of cancer cells is the ultimate hallmark of malignancy and accounts for approximately 90% of human cancer deaths. We investigated the role of acid sphingomyelinase (Asm) in the hematogenous metastasis of melanoma cells. Intravenous injection of B16F10 melanoma cells into wild-type mice resulted in multiple lung metastases, while Asm-deficient mice (Smpd1(-/-) mice) were protected from pulmonary tumor spread. Transplanting wild-type platelets into Asm-deficient mice reinstated tumor metastasis. Likewise, Asm-deficient mice were protected from hematogenous MT/ret melanoma metastasis to the spleen in a mouse model of spontaneous tumor metastasis. Human and mouse melanoma cells triggered activation and release of platelet secretory Asm, in turn leading to ceramide formation, clustering, and activation of ?5?1 integrins on melanoma cells finally leading to adhesion of the tumor cells. Clustering of integrins by applying purified Asm or C16 ceramide to B16F10 melanoma cells before intravenous injection restored trapping of tumor cells in the lung in Asm-deficient mice. This effect was revertable by arginine-glycine-aspartic acid peptides, which are known inhibitors of integrins, and by antibodies neutralizing ?1 integrins. These findings indicate that melanoma cells employ platelet-derived Asm for adhesion and metastasis. |Animals [MESH] |Cell Line, Tumor [MESH] |Melanoma/*secondary [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Neoplasm Metastasis/*physiopathology [MESH]Regulation of hematogenous tumor metastasis by acid sphingomyelinase (epmc).pdf DeepDyve Pubget Overpricing