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10.1073/pnas.1613113113 http://scihub22266oqcxt.onion/10.1073/pnas.1613113113 C5127329!5127329 !27821771     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27821771 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (47 ): 13414-13419 Nephropedia Template TP {{tp|p=27821771 |t=2016. Regulation of embryonic neurogenesis by germinal zone vasculature |pdf=|usr=}}{{27821771 }} gab.com Text Regulation of embryonic neurogenesis by germinal zone vasculature JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27821771 #FOAvip In the adult rodent brain, new neurons are born in two germinal regions that are associated with blood vessels, and blood vessels and vessel-derived factors are thought to regulate the activity of adult neural stem cells. Recently, it has been proposed that a vascular niche also regulates prenatal neurogenesis. Here we identify the mouse embryo hindbrain as a powerful model to study embryonic neurogenesis and define the relationship between neural progenitor cell (NPC) behavior and vessel growth. Using this model, we show that a subventricular vascular plexus (SVP) extends through a hindbrain germinal zone populated by NPCs whose peak mitotic activity follows a surge in SVP growth. Hindbrains genetically defective in SVP formation owing to constitutive NRP1 loss showed a premature decline in both NPC activity and hindbrain growth downstream of precocious cell cycle exit, premature neuronal differentiation, and abnormal mitosis patterns. Defective regulation of NPC activity was not observed in mice lacking NRP1 expression by NPCs, but instead in mice lacking NRP1 selectively in endothelial cells, yet was independent of vascular roles in hindbrain oxygenation. Therefore, germinal zone vascularization sustains NPC proliferation in the prenatal brain. Twit Text FOAVip Regulation of embryonic neurogenesis by germinal zone vasculature ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27821771 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27821771 #FOAvip English Wikipedia <ref>{{Cite pmid|27821771 }}</ref> Regulation of embryonic neurogenesis by germinal zone vasculature #MMPMID27821771 Tata M ; Wall I ; Joyce A ; Vieira JM ; Kessaris N ; Ruhrberg C Proc Natl Acad Sci U S A 2016[Nov]; 113 (47 ): 13414-13419 PMID27821771 show ga In the adult rodent brain, new neurons are born in two germinal regions that are associated with blood vessels, and blood vessels and vessel-derived factors are thought to regulate the activity of adult neural stem cells. Recently, it has been proposed that a vascular niche also regulates prenatal neurogenesis. Here we identify the mouse embryo hindbrain as a powerful model to study embryonic neurogenesis and define the relationship between neural progenitor cell (NPC) behavior and vessel growth. Using this model, we show that a subventricular vascular plexus (SVP) extends through a hindbrain germinal zone populated by NPCs whose peak mitotic activity follows a surge in SVP growth. Hindbrains genetically defective in SVP formation owing to constitutive NRP1 loss showed a premature decline in both NPC activity and hindbrain growth downstream of precocious cell cycle exit, premature neuronal differentiation, and abnormal mitosis patterns. Defective regulation of NPC activity was not observed in mice lacking NRP1 expression by NPCs, but instead in mice lacking NRP1 selectively in endothelial cells, yet was independent of vascular roles in hindbrain oxygenation. Therefore, germinal zone vascularization sustains NPC proliferation in the prenatal brain. |*Neurogenesis [MESH] |Animals [MESH] |Blood Vessels/*physiology [MESH] |Cell Proliferation [MESH] |Cell Self Renewal [MESH] |Endothelial Cells/metabolism [MESH] |Extracellular Matrix/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mitosis [MESH] |Neovascularization, Physiologic [MESH] |Neural Stem Cells/cytology/metabolism [MESH] |Neuropilin-1/metabolism [MESH] |Oxygen/metabolism [MESH] |Rhombencephalon/*blood supply/*embryology [MESH]Regulation of embryonic neurogenesis by germinal zone vasculature (epmc).pdf DeepDyve Pubget Overpricing