Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26405462
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cell+Mol+Bioeng
2013 ; 6
(4
): 418-430
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Regulation of chromosome speeds in mitosis
#MMPMID26405462
Betterton MD
; McIntosh JR
Cell Mol Bioeng
2013[Dec]; 6
(4
): 418-430
PMID26405462
show ga
When chromosome are being separated in preparation for cell division, their
motions are slow (~16 nm/s) relative to the speed at which many motor enzymes can
move their cellular cargoes (160-1000 nm/s and sometimes even faster) and at
which microtubules (MTs) depolymerize (~200 nm/s). Indeed, anaphase chromosome
speeds are so slow that viscous drag puts little load on the mechanisms that
generate the relevant forces [35]. Available evidence suggests that chromosome
speed is due to some form of regulation. For example, big and little chromosomes
move at about the same speed, chromosomes that have farther to go move faster
than others, and chromosome speed is affected by both temperature and an
experimentally applied load. In this essay we review data on these phenomena and
present our ideas about likely properties of the mechanisms that regulate
chromosome speed.