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2011 ; 22
(9
): 1005-11
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Regulation of blood vessel sprouting
#MMPMID22020130
Chappell JC
; Wiley DM
; Bautch VL
Semin Cell Dev Biol
2011[Dec]; 22
(9
): 1005-11
PMID22020130
show ga
Blood vessels are essential conduits of nutrients and oxygen throughout the body.
The formation of these vessels involves angiogenic sprouting, a complex process
entailing highly integrated cell behaviors and signaling pathways. In this
review, we discuss how endothelial cells initiate a vessel sprout through
interactions with their environment and with one another, particularly through
lateral inhibition. We review the composition of the local environment, which
contains an initial set of guidance cues to facilitate the proper outward
migration of the sprout as it emerges from a parent vessel. The long-range
guidance and sprout stability cues provided by soluble molecules, extracellular
matrix components, and interactions with other cell types are also discussed. We
also examine emerging evidence for mechanisms that govern sprout fusion with its
target and lumen formation.
|Animals
[MESH]
|Blood Vessels/cytology/*growth & development
[MESH]