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2018 ; 8
(ä): 119
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Regulation of Malignant Hematopoiesis by Bone Marrow Microenvironment
#MMPMID29740536
Asada N
Front Oncol
2018[]; 8
(ä): 119
PMID29740536
show ga
Hematopoietic stem cells (HSCs) that give rise to all kinds of hematopoietic
lineage cells on various demands throughout life are maintained in a specialized
microenvironment called "niche" in the bone marrow (BM). Defining niche cells and
unveiling its function have been the subject of intense study, and it is becoming
increasingly clear how niche cells regulate HSCs in normal hematopoiesis.
Leukemia stem cells (LSCs), which are able to produce leukemic cells and maintain
leukemic clones, are assumed to share common features with healthy HSCs.
Accumulating evidence suggests that LSCs reside in a specialized BM
microenvironment; moreover, LSCs could control and rebuild the microenvironment
to enhance their progression and survival. This article discusses the recent
advances in our knowledge of the microenvironment supporting malignant
hematopoiesis, including LSC niche.