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2015 ; 2015
(ä): 743169
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Regulation of Dendritic Cell Function in Inflammation
#MMPMID26229971
Said A
; Weindl G
J Immunol Res
2015[]; 2015
(ä): 743169
PMID26229971
show ga
Dendritic cells (DC) are professional antigen presenting cells and link the
innate and adaptive immune system. During steady state immune surveillance in
skin, DC act as sentinels against commensals and invading pathogens. Under
pathological skin conditions, inflammatory cytokines, secreted by surrounding
keratinocytes, dermal fibroblasts, and immune cells, influence the activation and
maturation of different DC populations including Langerhans cells (LC) and dermal
DC. In this review we address critical differences in human DC subtypes during
inflammatory settings compared to steady state. We also highlight the functional
characteristics of human DC subsets in inflammatory skin environments and skin
diseases including psoriasis and atopic dermatitis. Understanding the complex
immunoregulatory role of distinct DC subsets in inflamed human skin will be a key
element in developing novel strategies in anti-inflammatory therapy.