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2015 ; 7
(9
): 8127-51
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Regulation of Dendritic Cell Function by Vitamin D
#MMPMID26402698
Barragan M
; Good M
; Kolls JK
Nutrients
2015[Sep]; 7
(9
): 8127-51
PMID26402698
show ga
Studies over the last two decades have revealed profound immunomodulatory aspects
of vitamin D on various aspects of the immune system. This review will provide an
overview of Vitamin D metabolism, a description of dendritic cell subsets, and
highlight recent advances on the effects of vitamin D on dendritic cell function,
maturation, cytokine production and antigen presentation. The active form of
vitamin D, 1,25(OH)?D?, has important immunoregulatory and anti-inflammatory
effects. Specifically, the 1,25(OH)?D?-Vitamin D? complex can affect the
maturation and migration of many dendritic cell subsets, conferring a special
immunoregulatory role as well as tolerogenic properties affecting cytokine and
chemokine production. Furthermore, there have been many recent studies
demonstrating the effects of Vitamin D on allergic disease and autoimmunity. A
clear understanding of the effects of the various forms of Vitamin D will provide
new opportunities to improve human health.
|Adaptive Immunity
[MESH]
|Animals
[MESH]
|Calcitriol/immunology/*metabolism/therapeutic use
[MESH]
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