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Regulation of Cellular Metabolism and Hypoxia by p53
#MMPMID27371670
Humpton TJ
; Vousden KH
Cold Spring Harb Perspect Med
2016[Jul]; 6
(7
): ? PMID27371670
show ga
The p53 protein is essential for the implementation of the cellular response to
challenging environmental conditions. Reacting to stochastic nutrient stress, p53
integrates the activity of key metabolite-sensing pathways to coordinate an
appropriate cell response. During starvation, p53 activity augments cell survival
pathways, inhibits unnecessary growth, and promotes efficient nutrient
generation, utilization, and conservation. Similarly, during oxygen stress, p53
facilitates redirection of cellular metabolism toward energy generation through
nonoxidative means, the suppression of reactive oxygen species (ROS) generation,
and ROS detoxification-promoting cell survival. However, if adverse conditions
are too acute or persistent, p53 can switch roles to implement canonical cell
killing. The ability of p53 to regulate metabolism is a powerful feature of p53
biology that can both promote cell survival and act as a check on the
inappropriate proliferation of cancer cells.
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