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10.1016/bs.ctdb.2016.11.001 http://scihub22266oqcxt.onion/10.1016/bs.ctdb.2016.11.001 C5943083!5943083 !28236972     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28236972 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28236972 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Top+Dev+Biol 2017 ; 123 (ä): 365-397 Nephropedia Template TP {{tp|p=28236972 |t=2017. Regulation of Cell Polarity by PAR-1/MARK Kinase |pdf=|usr=}}{{28236972 }} gab.com Text Regulation of Cell Polarity by PAR-1/MARK Kinase JO: Curr Top Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=28236972 #FOAvip PAR-1/MARK kinases are conserved serine/threonine kinases that are essential regulators of cell polarity. PAR-1/MARK kinases localize and function in opposition to the anterior PAR proteins to control the asymmetric distribution of factors in a wide variety polarized cells. In this review, we discuss the mechanisms that control the localization and activity of PAR-1/MARK kinases, including their antagonistic interactions with the anterior PAR proteins. We focus on the role PAR-1 plays in the asymmetric division of the Caenorhabditis elegans zygote, in the establishment of the anterior/posterior axis in the Drosophila oocyte and in the control of microtubule dynamics in mammalian neurons. In addition to conserved aspects of PAR-1 biology, we highlight the unique ways in which PAR-1 acts in these distinct cell types to orchestrate their polarization. Finally, we review the connections between disruptions in PAR-1/MARK function and Alzheimer's disease and cancer. Twit Text FOAVip Regulation of Cell Polarity by PAR-1/MARK Kinase ????Curr Top Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=28236972 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28236972 #FOAvip English Wikipedia <ref>{{Cite pmid|28236972 }}</ref> Regulation of Cell Polarity by PAR-1/MARK Kinase #MMPMID28236972 Wu Y ; Griffin EE Curr Top Dev Biol 2017[]; 123 (ä): 365-397 PMID28236972 show ga PAR-1/MARK kinases are conserved serine/threonine kinases that are essential regulators of cell polarity. PAR-1/MARK kinases localize and function in opposition to the anterior PAR proteins to control the asymmetric distribution of factors in a wide variety polarized cells. In this review, we discuss the mechanisms that control the localization and activity of PAR-1/MARK kinases, including their antagonistic interactions with the anterior PAR proteins. We focus on the role PAR-1 plays in the asymmetric division of the Caenorhabditis elegans zygote, in the establishment of the anterior/posterior axis in the Drosophila oocyte and in the control of microtubule dynamics in mammalian neurons. In addition to conserved aspects of PAR-1 biology, we highlight the unique ways in which PAR-1 acts in these distinct cell types to orchestrate their polarization. Finally, we review the connections between disruptions in PAR-1/MARK function and Alzheimer's disease and cancer. |*Cell Polarity [MESH] |Animals [MESH] |Asymmetric Cell Division [MESH] |Body Patterning [MESH] |Caenorhabditis elegans/cytology/embryology/enzymology [MESH] |Drosophila/cytology/embryology [MESH]Regulation of Cell Polarity by PAR-1/MARK Kinase (epmc).pdf DeepDyve Pubget Overpricing