Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18598214
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18598214
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Annu+Rev+Cell+Dev+Biol
2008 ; 24
(ä): 475-99
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Regulation of APC/C activators in mitosis and meiosis
#MMPMID18598214
Pesin JA
; Orr-Weaver TL
Annu Rev Cell Dev Biol
2008[]; 24
(ä): 475-99
PMID18598214
show ga
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin
ligase that triggers the degradation of multiple substrates during mitosis.
Cdc20/Fizzy and Cdh1/Fizzy-related activate the APC/C and confer substrate
specificity through complex interactions with both the core APC/C and substrate
proteins. The regulation of Cdc20 and Cdh1 is critical for proper APC/C activity
and occurs in multiple ways: targeted protein degradation, phosphorylation, and
direct binding of inhibitory proteins. During the specialized divisions of
meiosis, the activity of the APC/C must be modified to achieve proper chromosome
segregation. Recent studies show that one way in which APC/C activity is modified
is through the use of meiosis-specific APC/C activators. Furthermore, regulation
of the APC/C during meiosis is carried out by both mitotic regulators of the
APC/C as well as meiosis-specific regulators. Here, we review the regulation of
APC/C activators during mitosis and the role and regulation of the APC/C during
female meiosis.
free
free
free
