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10.1146/annurev-biochem-051810-093157 http://scihub22266oqcxt.onion/10.1146/annurev-biochem-051810-093157 C4332854!4332854 !24606138     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24606138 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Biochem 2014 ; 83 (ä): 671-96 Nephropedia Template TP {{tp|p=24606138 |t=2014. Regulating the chromatin landscape: structural and mechanistic perspectives |pdf=|usr=}}{{24606138 }} gab.com Text Regulating the chromatin landscape: structural and mechanistic perspectives JO: Annu Rev Biochem http://www.kidney.de/pget.php?&tw=1&pmid=24606138 #FOAvip A large family of chromatin remodelers that noncovalently modify chromatin is crucial in cell development and differentiation. They are often the targets of cancer, neurological disorders, and other human diseases. These complexes alter nucleosome positioning, higher-order chromatin structure, and nuclear organization. They also assemble chromatin, exchange out histone variants, and disassemble chromatin at defined locations. We review aspects of the structural organization of these complexes, the functional properties of their protein domains, and variation between complexes. We also address the mechanistic details of these complexes in mobilizing nucleosomes and altering chromatin structure. A better understanding of these issues will be vital for further analyses of subunits of these chromatin remodelers, which are being identified as targets in human diseases by NGS (next-generation sequencing). Twit Text FOAVip Regulating the chromatin landscape: structural and mechanistic perspectives ????Annu Rev Biochem http://www.kidney.de/pget.php?&tw=1&pmid=24606138 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24606138 #FOAvip English Wikipedia <ref>{{Cite pmid|24606138 }}</ref> Regulating the chromatin landscape: structural and mechanistic perspectives #MMPMID24606138 Bartholomew B Annu Rev Biochem 2014[]; 83 (ä): 671-96 PMID24606138 show ga A large family of chromatin remodelers that noncovalently modify chromatin is crucial in cell development and differentiation. They are often the targets of cancer, neurological disorders, and other human diseases. These complexes alter nucleosome positioning, higher-order chromatin structure, and nuclear organization. They also assemble chromatin, exchange out histone variants, and disassemble chromatin at defined locations. We review aspects of the structural organization of these complexes, the functional properties of their protein domains, and variation between complexes. We also address the mechanistic details of these complexes in mobilizing nucleosomes and altering chromatin structure. A better understanding of these issues will be vital for further analyses of subunits of these chromatin remodelers, which are being identified as targets in human diseases by NGS (next-generation sequencing). |*Chromatin Assembly and Disassembly [MESH] |Adenosine Triphosphate/chemistry [MESH] |Animals [MESH] |Cell Differentiation [MESH] |Chromatin/*chemistry [MESH] |Crystallography, X-Ray/methods [MESH] |DNA/*chemistry [MESH] |Humans [MESH] |Nucleosomes/*chemistry/metabolism [MESH] |Protein Interaction Mapping [MESH] |Protein Structure, Tertiary [MESH]Regulating the chromatin landscape: structural and mechanistic perspec(epmc).pdf DeepDyve Pubget Overpricing