Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25983525
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Rare+Metals
2015 ; 34
(3
): 143-155
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Regenerative Engineering and Bionic Limbs
#MMPMID25983525
James R
; Laurencin CT
Rare Metals
2015[Mar]; 34
(3
): 143-155
PMID25983525
show ga
Amputations of the upper extremity are severely debilitating, current treatments
support very basic limb movement, and patients undergo extensive physiotherapy
and psychological counselling. There is no prosthesis that allows the amputees
near-normal function. With increasing number of amputees due to injuries
sustained in accidents, natural calamities and international conflicts, there is
a growing requirement for novel strategies and new discoveries. Advances have
been made in technological, material and in prosthesis integration where
researchers are now exploring artificial prosthesis that integrate with the
residual tissues and function based on signal impulses received from the residual
nerves. Efforts are focused on challenging experts in different disciplines to
integrate ideas and technologies to allow for the regeneration of injured
tissues, recording on tissue signals and feed-back to facilitate responsive
movements and gradations of muscle force. A fully functional replacement and
regenerative or integrated prosthesis will rely on interface of biological
process with robotic systems to allow individual control of movement such as at
the elbow, forearm, digits and thumb in the upper extremity. Regenerative
engineering focused on the regeneration of complex tissue and organ systems will
be realized by the cross-fertilization of advances over the past thirty years in
the fields of tissue engineering, nanotechnology, stem cell science, and
developmental biology. The convergence of toolboxes crated within each discipline
will allow interdisciplinary teams from engineering, science, and medicine to
realize new strategies, mergers of disparate technologies, such as biophysics,
smart bionics, and the healing power of the mind. Tackling the clinical
challenges, interfacing the biological process with bionic technologies,
engineering biological control of the electronic systems, and feed-back will be
the important goals in regenerative engineering over the next two decades.