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10.1074/jbc.M114.568998 http://scihub22266oqcxt.onion/10.1074/jbc.M114.568998 C4067184!4067184 !24817115     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24817115 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2014 ; 289 (25 ): 17454-67 Nephropedia Template TP {{tp|p=24817115 |t=2014. Reduction of proteinuria through podocyte alkalinization |pdf=|usr=}}{{24817115 }} gab.com Text Reduction of proteinuria through podocyte alkalinization JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24817115 #FOAvip Podocytes are highly differentiated cells and critical elements for the filtration barrier of the kidney. Loss of their foot process (FP) architecture (FP effacement) results in urinary protein loss. Here we show a novel role for the neutral amino acid glutamine in structural and functional regulation of the kidney filtration barrier. Metabolic flux analysis of cultured podocytes using genetic, toxic, and immunologic injury models identified increased glutamine utilization pathways. We show that glutamine uptake is increased in diseased podocytes to couple nutrient support to increased demand during the disease state of FP effacement. This feature can be utilized to transport increased amounts of glutamine into damaged podocytes. The availability of glutamine determines the regulation of podocyte intracellular pH (pHi). Podocyte alkalinization reduces cytosolic cathepsin L protease activity and protects the podocyte cytoskeleton. Podocyte glutamine supplementation reduces proteinuria in LPS-treated mice, whereas acidification increases glomerular injury. In summary, our data provide a metabolic opportunity to combat urinary protein loss through modulation of podocyte amino acid utilization and pHi. Twit Text FOAVip Reduction of proteinuria through podocyte alkalinization ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24817115 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24817115 #FOAvip English Wikipedia <ref>{{Cite pmid|24817115 }}</ref> Reduction of proteinuria through podocyte alkalinization #MMPMID24817115 Altintas MM ; Moriwaki K ; Wei C ; Möller CC ; Flesche J ; Li J ; Yaddanapudi S ; Faridi MH ; Gödel M ; Huber TB ; Preston RA ; Jiang JX ; Kerjaschki D ; Sever S ; Reiser J J Biol Chem 2014[Jun]; 289 (25 ): 17454-67 PMID24817115 show ga Podocytes are highly differentiated cells and critical elements for the filtration barrier of the kidney. Loss of their foot process (FP) architecture (FP effacement) results in urinary protein loss. Here we show a novel role for the neutral amino acid glutamine in structural and functional regulation of the kidney filtration barrier. Metabolic flux analysis of cultured podocytes using genetic, toxic, and immunologic injury models identified increased glutamine utilization pathways. We show that glutamine uptake is increased in diseased podocytes to couple nutrient support to increased demand during the disease state of FP effacement. This feature can be utilized to transport increased amounts of glutamine into damaged podocytes. The availability of glutamine determines the regulation of podocyte intracellular pH (pHi). Podocyte alkalinization reduces cytosolic cathepsin L protease activity and protects the podocyte cytoskeleton. Podocyte glutamine supplementation reduces proteinuria in LPS-treated mice, whereas acidification increases glomerular injury. In summary, our data provide a metabolic opportunity to combat urinary protein loss through modulation of podocyte amino acid utilization and pHi. |Animals [MESH] |Biological Transport, Active/genetics/immunology [MESH] |Cells, Cultured [MESH] |Cytoskeleton/genetics/immunology/metabolism/pathology [MESH] |Hydrogen-Ion Concentration [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Podocytes/immunology/*metabolism/pathology [MESH]Reduction of proteinuria through podocyte alkalinization (epmc).pdf DeepDyve Pubget Overpricing