Redox Modulations, Antioxidants, and Neuropsychiatric Disorders
#MMPMID26640614
Fraunberger EA
; Scola G
; Laliberté VL
; Duong A
; Andreazza AC
Oxid Med Cell Longev
2016[]; 2016
(?): 4729192
PMID26640614
show ga
Although antioxidants, redox modulations, and neuropsychiatric disorders have
been widely studied for many years, the field would benefit from an integrative
and corroborative review. Our primary objective is to delineate the biological
significance of compounds that modulate our redox status (i.e., reactive species
and antioxidants) as well as outline their current role in brain health and the
impact of redox modulations on the severity of illnesses. Therefore, this review
will not enter into the debate regarding the perceived medical legitimacy of
antioxidants but rather seek to clarify their abilities and limitations. With
this in mind, antioxidants may be interpreted as natural products with
significant pharmacological actions in the body. A renewed understanding of these
often overlooked compounds will allow us to critically appraise the current
literature and provide an informed, novel perspective on an important healthcare
issue. In this review, we will introduce the complex topics of redox modulations
and their role in the development of select neuropsychiatric disorders.
|*Mental Disorders/drug therapy/metabolism
[MESH]
|*Nervous System Diseases/drug therapy/metabolism
[MESH]
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