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2018 ; 11
(ä): 175-185
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Recurrent candidal intertrigo: challenges and solutions
#MMPMID29713190
Metin A
; Dilek N
; Bilgili SG
Clin Cosmet Investig Dermatol
2018[]; 11
(ä): 175-185
PMID29713190
show ga
Intertrigo is a common inflammatory dermatosis of opposing skin surfaces that can
be caused by a variety of infectious agents, most notably candida, under the
effect of mechanical and environmental factors. Symptoms such as pain and itching
significantly decrease quality of life, leading to high morbidity. A multitude of
predisposing factors, particularly obesity, diabetes mellitus, and
immunosuppressive conditions facilitate both the occurrence and recurrence of the
disease. The diagnosis of candidal intertrigo is usually based on clinical
appearance. However, a range of laboratory studies from simple tests to advanced
methods can be carried out to confirm the diagnosis. Such tests are especially
useful in treatment-resistant or recurrent cases for establishing a differential
diagnosis. The first and key step of management is identification and correction
of predisposing factors. Patients should be encouraged to lose weight, followed
up properly after endocrinologic treatment and intestinal colonization or
periorificial infections should be medically managed, especially in recurrent and
resistant cases. Medical treatment of candidal intertrigo usually requires
topical administration of nystatin and azole group antifungals. In this context,
it is also possible to use magistral remedies safely and effectively. In case of
predisposing immunosuppressive conditions or generalized infections, novel
systemic agents with higher potency may be required.