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2016 ; 36
(42
): 10707-10722
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Reconnecting Eye to Brain
#MMPMID27798125
Crair MC
; Mason CA
J Neurosci
2016[Oct]; 36
(42
): 10707-10722
PMID27798125
show ga
Although much is known about the regenerative capacity of retinal ganglion cells,
very significant barriers remain in our ability to restore visual function
following traumatic injury or disease-induced degeneration. Here we summarize our
current understanding of the factors regulating axon guidance and target
engagement in regenerating axons, and review the state of the field of neural
regeneration, focusing on the visual system and highlighting studies using other
model systems that can inform analysis of visual system regeneration. This
overview is motivated by a Society for Neuroscience Satellite meeting,
"Reconnecting Neurons in the Visual System," held in October 2015 sponsored by
the National Eye Institute as part of their "Audacious Goals Initiative" and
co-organized by Carol Mason (Columbia University) and Michael Crair (Yale
University). The collective wisdom of the conference participants pointed to
important gaps in our knowledge and barriers to progress in promoting the
restoration of visual system function. This article is thus a summary of our
existing understanding of visual system regeneration and provides a blueprint for
future progress in the field.