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10.1007/s00417-015-3142-8 http://scihub22266oqcxt.onion/10.1007/s00417-015-3142-8 C4769982!4769982!26311262     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26311262.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Graefes+Arch+Clin+Exp+Ophthalmol 2016 ; 254 (5): 865-72 Nephropedia Template TP {{tp|p=26311262|t=2016. Recessive Stargardt Disease Phenocopying Hydroxychloroquine Retinopathy |pdf=|usr=}}{{26311262}} gab.com Text Recessive Stargardt Disease Phenocopying Hydroxychloroquine Retinopathy JO: Graefes Arch Clin Exp Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=26311262 #FOAvip Purpose: To describe a series of Stargardt disease (STGD1) patients exhibiting a phenotype usually associated with hydroxychloroquine (HCQ) retinopathy on spectral domain-optical coherence tomography (SD-OCT). Methods: Observational case series from Columbia University Medical Center involving 8 patients with genetically-confirmed STGD1. Patients selected for the study presented no history of HCQ use. Horizontal macular SD-OCT scans and accompanying 488nm autofluorescence (AF) images, color fundus photographs, and full-field electroretinograms were analyzed. Results: All study patients exhibited an abrupt thinning of the parafoveal region or disruption of the outer retinal layers on SD-OCT resembling the transient HCQ retinopathy phenotype. Funduscopy and AF imaging revealed variations of bull?s eye maculopathy (BEM). Five patients exhibited local fleck-like deposits around the lesion. Genetic screening confirmed two disease-causing ABCA4 mutations in 5 patients and one mutation in 3 patients. Conclusions: A transient SD- OCT phenotype ascribed to patients with HCQ retinopathy is associated with an early subtype of STGD1. This finding may also present with HCQ retinopathy-like BEM lesions on AF imaging and funduscopy. A phenotypic overlap may not be surprising given certain shared mechanistic disease processes between the two conditions. A thorough work-up, including screening of genes that are causal in retinal dystrophies associated with foveal sparing, may prevent the misdiagnoses of more ambiguous cases. Twit Text FOAVip Recessive Stargardt Disease Phenocopying Hydroxychloroquine Retinopathy ????Graefes Arch Clin Exp Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=26311262 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26311262 #FOAvip English Wikipedia <ref>{{Cite pmid|26311262}}</ref> Recessive Stargardt Disease Phenocopying Hydroxychloroquine Retinopathy #MMPMID26311262 Noupuu K; Lee W; Zernant J; Greenstein VC; Tsang S; Allikmets R Graefes Arch Clin Exp Ophthalmol 2016[May]; 254 (5): 865-72 PMID26311262show ga Purpose: To describe a series of Stargardt disease (STGD1) patients exhibiting a phenotype usually associated with hydroxychloroquine (HCQ) retinopathy on spectral domain-optical coherence tomography (SD-OCT). Methods: Observational case series from Columbia University Medical Center involving 8 patients with genetically-confirmed STGD1. Patients selected for the study presented no history of HCQ use. Horizontal macular SD-OCT scans and accompanying 488nm autofluorescence (AF) images, color fundus photographs, and full-field electroretinograms were analyzed. Results: All study patients exhibited an abrupt thinning of the parafoveal region or disruption of the outer retinal layers on SD-OCT resembling the transient HCQ retinopathy phenotype. Funduscopy and AF imaging revealed variations of bull?s eye maculopathy (BEM). Five patients exhibited local fleck-like deposits around the lesion. Genetic screening confirmed two disease-causing ABCA4 mutations in 5 patients and one mutation in 3 patients. Conclusions: A transient SD- OCT phenotype ascribed to patients with HCQ retinopathy is associated with an early subtype of STGD1. This finding may also present with HCQ retinopathy-like BEM lesions on AF imaging and funduscopy. A phenotypic overlap may not be surprising given certain shared mechanistic disease processes between the two conditions. A thorough work-up, including screening of genes that are causal in retinal dystrophies associated with foveal sparing, may prevent the misdiagnoses of more ambiguous cases. äRecessive Stargardt Disease Phenocopying Hydroxychloroquine Retinopath(epmc).pdf DeepDyve Pubget Overpricing