Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s00417-015-3142-8 http://scihub22266oqcxt.onion/10.1007/s00417-015-3142-8 C4769982!4769982 !26311262     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26311262 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26311262 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Graefes+Arch+Clin+Exp+Ophthalmol 2016 ; 254 (5 ): 865-72 Nephropedia Template TP {{tp|p=26311262 |t=2016. Recessive Stargardt disease phenocopying hydroxychloroquine retinopathy |pdf=|usr=}}{{26311262 }} gab.com Text Recessive Stargardt disease phenocopying hydroxychloroquine retinopathy JO: Graefes Arch Clin Exp Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=26311262 #FOAvip PURPOSE: To describe a series of patients with Stargardt disease (STGD1) exhibiting a phenotype usually associated with hydroxychloroquine (HCQ) retinopathy on spectral domain-optical coherence tomography (SD-OCT). METHODS: Observational case series from Columbia University Medical Center involving eight patients with genetically-confirmed STGD1. Patients selected for the study presented no history of HCQ use. Horizontal macular SD-OCT scans and accompanying 488-nm autofluorescence (AF) images, color fundus photographs, and full-field electroretinograms were analyzed. RESULTS: All study patients exhibited an abrupt thinning of the parafoveal region or disruption of the outer retinal layers on SD-OCT resembling the transient HCQ retinopathy phenotype. Funduscopy and AF imaging revealed variations of bull's eye maculopathy (BEM). Five patients exhibited local fleck-like deposits around the lesion. Genetic screening confirmed two disease-causing ABCA4 mutations in five patients and one mutation in three patients. CONCLUSIONS: A transient SD-OCT phenotype ascribed to patients with HCQ retinopathy is associated with an early subtype of STGD1. This finding may also present with HCQ retinopathy-like BEM lesions on AF imaging and funduscopy. A possible phenotypic overlap is unsurprising, given certain shared mechanistic disease processes between the two conditions. A thorough work-up, including screening of genes that are causal in retinal dystrophies associated with foveal sparing, may prevent misdiagnosis of more ambiguous cases. Twit Text FOAVip Recessive Stargardt disease phenocopying hydroxychloroquine retinopathy ????Graefes Arch Clin Exp Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=26311262 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26311262 #FOAvip English Wikipedia <ref>{{Cite pmid|26311262 }}</ref> Recessive Stargardt disease phenocopying hydroxychloroquine retinopathy #MMPMID26311262 Nõupuu K ; Lee W ; Zernant J ; Greenstein VC ; Tsang S ; Allikmets R Graefes Arch Clin Exp Ophthalmol 2016[May]; 254 (5 ): 865-72 PMID26311262 show ga PURPOSE: To describe a series of patients with Stargardt disease (STGD1) exhibiting a phenotype usually associated with hydroxychloroquine (HCQ) retinopathy on spectral domain-optical coherence tomography (SD-OCT). METHODS: Observational case series from Columbia University Medical Center involving eight patients with genetically-confirmed STGD1. Patients selected for the study presented no history of HCQ use. Horizontal macular SD-OCT scans and accompanying 488-nm autofluorescence (AF) images, color fundus photographs, and full-field electroretinograms were analyzed. RESULTS: All study patients exhibited an abrupt thinning of the parafoveal region or disruption of the outer retinal layers on SD-OCT resembling the transient HCQ retinopathy phenotype. Funduscopy and AF imaging revealed variations of bull's eye maculopathy (BEM). Five patients exhibited local fleck-like deposits around the lesion. Genetic screening confirmed two disease-causing ABCA4 mutations in five patients and one mutation in three patients. CONCLUSIONS: A transient SD-OCT phenotype ascribed to patients with HCQ retinopathy is associated with an early subtype of STGD1. This finding may also present with HCQ retinopathy-like BEM lesions on AF imaging and funduscopy. A possible phenotypic overlap is unsurprising, given certain shared mechanistic disease processes between the two conditions. A thorough work-up, including screening of genes that are causal in retinal dystrophies associated with foveal sparing, may prevent misdiagnosis of more ambiguous cases. |ATP-Binding Cassette Transporters/*genetics [MESH] |Adult [MESH] |Antimalarials/*toxicity [MESH] |Child [MESH] |Electroretinography [MESH] |Female [MESH] |Genes, Recessive [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Humans [MESH] |Hydroxychloroquine/*toxicity [MESH] |Macular Degeneration/*congenital/diagnosis/genetics [MESH] |Male [MESH] |Middle Aged [MESH] |Mutation [MESH] |Phenotype [MESH] |Retinal Diseases/chemically induced/*diagnosis [MESH] |Retrospective Studies [MESH] |Stargardt Disease [MESH] |Tomography, Optical Coherence [MESH]Recessive Stargardt disease phenocopying hydroxychloroquine retinopath(epmc).pdf DeepDyve Pubget Overpricing